KMID : 0384320070280110860
|
|
Korean Journal of Family Medicine 2007 Volume.28 No. 11 p.860 ~ p.866
|
|
The Relationship between Reduced Lung Function and High Sensitive C-reactive Protein in Healthy Adult Men
|
|
Lee Jung-Woon
Paek Yu-Jin
|
|
Abstract
|
|
|
Background: Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function with obstructive and restrictive lung diseases. We hypothesized that forced expiratory volume in 1 second (FEV1) within the normal range is inversely associated with high sensitive C-reactive protein (hs-CRP), as a marker of chronic inflammation in healthy Korean adult men.
Methods: We analyzed the association of hs-CRP with pulmonary function test including FEV1, components of
metabolic syndrome among male participants (n=3,736), more than 20 years old who had visited a health promotion
center at a university hospital between January and December, 2006.
Results: In this cross-sectional study, there was an inverse association between hs-CRP levels and quartiles of FEV1 (P for trend£¼0.0001) after adjusting for age, smoking status, waist circumference, glucose, triglyceride, and
HDL-cholesterol. A similar association was present in non-smoking subjects, but there was no significant trend (P for trend=0.115) whereas it was significant in smoking subjects (P for trend£¼0.0001), and in ex-smoking subjects (P for trend=0.006). The odds ratios of having elevated hs-CRP (£¾2.2 mg/L) across FEV1 quartiles, with the lowest quartile (Q1) as the reference group was 1.01 (0.75 ¡1.35) in Q2, 1.24 (0.93¡1.65) in Q3, 1.52 (1.15¡2.01) in Q4 after adjusting for the confounding variables.
Conclusion: The decline of FEV1 within the normal range was inversely associated with low grade inflammation as measured by hs-CRP. This result showed that systemic inflammation may be linked to early impaired pulmonary
function in healthy adult men.
|
|
KEYWORD
|
|
high sensitive C-reactive protein, forced expiratory volume, respiratory function tests, systemic inflammation, male
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|